Take a look at advantages and disadvantages of horizontal form factor bioreactors and fermentors.
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INTRODUCTION - Vertically oriented vessels have dominated fermentor and bioreactor design for well over 50 years. This is irrespective of stainless steel (SS) vessels or single-use (SU) bags. The single-use bag design in the range of 25 Liter (L) through 2000L has for good reason been an extension of existing SS vertical systems to replicate known geometry. However at large scale this has provided some challenges in the world of microbial fermentors. Let’s take a look at the advantages / disadvantages of going to a horizontal form factor!